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| Cognitive Function in Aged Ovariectomized
Female Rhesus Monkeys Full text free at http://www.apa.org/journals/bne/bne1143506.html
Agn?s Lacreuse Division of Neuroscience Yerkes Regional Primate
Research Center Emory University
James G. Herndon Division of Neuroscience Yerkes Regional Primate
Research Center Emory University
Mark B. Moss Department of Anatomy and Neurobiology Boston University
School of Medicine
ABSTRACT To determine whether ovariectomy exacerbates age-related
Cognitive decline, the performance of 6 aged monkeys that had
been ovariectomized early in life (OVX-Aged) was compared to that
of 8 age-matched controls with intact ovaries (INT-Aged) and that
of 5 young controls with intact ovaries (INT-Young) in tasks of
visual recognition memory, object and spatial memory, and executive
function. The OVX-Aged monkeys were marginally more impaired than
the INT-Aged monkeys on the delayed nonmatching-to-sample with
a 600-s delay. In contrast, they performed significantly better
than the INT-Aged controls on the spatial condition of the delayed
recognition span test. The hypothesis that prolonged estrogenic
deprivation may exaggerate the age-related decline in visual recognition
memory will require additional support. However, the findings
suggest that long-term ovariectomy may protect against the development
with aging of spatial memory deficits. |
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